Product ID:AMPHOTERICIN B FOR INJECTION
MSDS Date:01/01/1994
FSC:6505
NIIN:00-962-4386
MSDS Number: BXCGK

FUJISAWA USA, INC.

3 PARKWAY NORTH
DEERFIELD, IL 60015-2548
US

Emergency Phone: 708-317-8202/800-727-7003 (24 HOUR)

Info Phone: 708-317-8800

Preparer: CHRISTINA J. BARRINGTON

Cage: 0K706

FUJISAWA USA, INC.

DEERFIELD, IL 60015-2548 US

Telephone: 708-317-0800 OR 800-888-7704

Cage: 0K706

AMPHOTERICIN B (50 MG/VIAL)

CAS: 1397-89-3

RTECS: BU2625000

SODIUM DESOXYCHOLATE (41 MG/VIAL)

CAS: 302-95-4

RTECS: FZ2250000

SODIUM PHOSPHATES (20.2 MG, PH ADJUSTED)

LD50 LC50 Mixture:LD50 (MOUSE,IV) IS 4 MG/KG.
Routes of Entry: Inhalation:NO Skin:NO Ingestion:NO
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:TARGET ORGANS:EYES, SKIN, RESPIRATORY
TRACT. ACUTE- THIS PRODUCT IS INTENDED FOR THERAPEUTIC USE ONLY
WHEN PRESCRIBED BY A PHYSICIAN. OCCUPATIONAL EXPOSURE HAS NOT BEEN
FULLY INVESTIGATED. MAY CAUSE E YES, SKIN AND RESPIRATORY TRACT
IRRITATION. INGESTION IS UNKNOWN. CHRONIC- HYPERSENSITIVITY
REACTIONS MAY OCCUR.
Explanation of Carcinogenicity:NONE
Effects of Overexposure:IRRITATION
Medical Cond Aggravated by Exposure:INDIVIDUALS WITH PRE-EXISTING
DISEASES OF SKIN, RESPIRATORY TRACT MAY HAVE INCREASED
SUSCEPTIBILITY TO THE TOXICITY OF EXCESSIVE EXPOSURES.

First Aid:CALL A DOCTOR IF SYMPTOMS PERSIST. EYE:IMMEDIATELY FLUSH WITH
WATER FOR 15 MINUTES, HOLDING EYELIDS OPEN. CALL PHYSICIAN.
SKIN:FLUSH WITH PLENTY OF WATER. INHALED:REMOVE TO FRESH AIR.
PROVIDE CPR/OXYG EN IF NEEDED. ORAL:IF CONSCIOUS, FLUSH MOUTH OUT
WITH WATER IMMEDIATELY. CALL A PHYSICIAN/POISON CONTROL CENTER
IMMEDIATELY. FOR ADVERSE DRUG REACTION INFORMATION CALL (708)
317-5937.

Flash Point:NONE
Extinguishing Media:WATER SPRAY, CARBON DIOXIDE, SAND, FOAM/DRY
CHEMICAL. WATER SPRAY MAY BE USED TO KEEP FIRE EXPOSED CONTAINERS
COOL.
Fire Fighting Procedures:WEAR PROTECTIVE CLOTHING AND NIOSH-APPROVED
SELF-CONTAINED BREATHING APPARATUS. IT EMITS TOXIC FUMES.
Unusual Fire/Explosion Hazard:COMBUSTIBLE POWDER.

Spill Release Procedures:WEAR PROTECTIVE EQUIPMENT. VACUUM OR ABSORB
SPILL WITH VERMICULITE OR OTHER INERT MATERIAL. PLACE IN A
CONTAINER FOR CHEMICAL WASTE. CLEAN AREA WITH SOAP AND WATER.
Neutralizing Agent:NOT RELEVANT

Handling and Storage Precautions:STORE IN COOL, DRY, VENTILATED AREA.
PROTECT FROM LIGHT AND FREEZING. KEEP OUT OF REACH OF CHILDREN.
Other Precautions:AS A GENERAL RULE, WHEN HANDLING PHARMACEUTICAL
PRODUCTS, AVOID ALL FORMS OF CONTACT AND INHALATION OF DUST, FUMES,
MISTS, AND/OR VAPORS ASSOCIATED WITH THE PRODUCT. WASH THOROUGHLY
AFTER HANDLING AND BEFORE EATING OR DRINKING.

Respiratory Protection:NONE SHOULD BE NEEDED.
Ventilation:ADEQUATE
Protective Gloves:LATEX RECOMMENDED
Eye Protection:SAFETY GLASSES/GOGGLES RECOMMENDED
Other Protective Equipment:EYE WASH STATION, LAB COAT
Work Hygienic Practices:OBSERVE GOOD PERSONAL HYGIENE PRACTICES AND
RECOMMENDED PROCEDURES. DO NOT WEAR CONTAMINATED CLOTHING.
Supplemental Safety and Health

HCC:N1
NRC/State Lic Num:NOT RELEVANT
Viscosity:NOT RELEVANT
Evaporation Rate & Reference:NOT RELEVANT
Solubility in Water:INSOLUBLE
Appearance and Odor:YELLOW/ORANGE LYOPHOLIZED POWDER - ODORLESS

Stability Indicator/Materials to Avoid:YES
Stability Condition to Avoid:LIGHT AND FREEZING
Hazardous Decomposition Products:OXIDES OF NITROGEN, OXIDES OF
PHOSPHORUS, SMOKE MAY BE FORMED.

Waste Disposal Methods:DISPOSE OF IN ACCORDANCE WITH ALL LOCAL, STATE
AND FEDERAL REGULATIONS.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.